Convergent binding sites

Molecular mechanics and dynamics calculations have shown that the preorganization of 21 for cation or anion binding and recognition results from its high connectivity and its preformed cavity with converging binding sites and fairly fixed size [1.45,2.36b]. 

Supermolecules generally comprise a host component with convergent binding sites and a guest component with divergent binding sites. 

Non-covalent bonds include ionic and dipolar interactions, hydrogen bonds, aromatic interactions (jt-jt, cation-jt and anion-7t), closed shell interactions and van der Waals interactions. Supermolecules generally comprise a host component with convergent binding sites and a guest component with divergent binding sites. 

SYNTHESIS AND COMPLEXING PROPERTIES OF A CHIRAL MACROCYCLIC MOLECULAR RECEPTOR WITH CONVERGENT BINDING SITES... 

It is well known that crown ethers form inclusion complexes with ion pairs in aprotic solvents. PhenyIboronic cyclic esters form adducts with amines 3, making them good candidates as convergent binding sites for amino groups. Linking these specific tnndinn sites with a chiral residue was the aim of this work as well as an examination... 

Fietraszklewicz, M. - Synthesis and complexlng properties of a chiral macrocyclic molecular receptor with convergent binding sites... 

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