Conus marmoreus

Figure 6 Venomous marine cone snails, (a) Geography cone Conus geographus (Public domain)) (b) Queen Victoria cone [Conus victoriae)-, (c) cloth of gold cone [Conus textile), (d) marble cone [Conus marmoreus (Public domain)) (e) closing view of proboscis with toxoglossan cone snail (f) microscope picture of toxoglossan from Conus consors. Photos (b), (c), (e),...

Xen-2174 (220) (isolated from the snail Conus marmoreus) 13-Amino-acid peptide (a conotoxin) Xen-2174 (220) Neurology (Pain) Inhibits norepinephrine transporter (NET) Phase II (against acute postoperative pain and chronic pain in cancer patient) Xenome 970-973... 

Glacontryphan-M N7S7CPWHPWC purpurascens Conus marmoreus m Ca + channel... 

Hansson, K., Ma, X., Eliasson, L., Czerwiec, E., Furie, B., Furie, B.C., Rorsman, P., and Stenflo, J. (2004) The first y-carboxyglutamic acid-containing contryphan - A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus. J. Biol. Chem., 279,32453-32463. 

Conotoxins with the co-type 6-Cys/4-loop framework (C—C—CC—C—-C) are the most abundant group of peptides isolated from Conus venoms so far. This structural class encompasses at least four known pharmacological classes co-conotoxins that block voltage-sensitive calcium channels, 5-conotoxins that retard sodium channel inactivation, the sodium channel blocker conotoxin-GS, and two peptides recently found in C. marmoreus that affect both sodium and calcium currents. In addition, three co-type 6-Cys/4-Ioop peptides with still unknown targets have been found in C. textile (Cruz et al., 1992) and C. quercinus (Abogadie et al., 1990 Olivera et al., 1990). 

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