Controlled-release kinetics

Because of the pH-independent dissolution profile of Eudragit RS 100 and RSPM, the dosage forms prepared with these polymers offer better controlled release kinetics than those with S 100 and L 100, as the solubilities of the latter are pH dependent. 

Simplified Procedure for Measuring Controlled-Release Kinetics... 

Potential for controlled release implants are available which deliver drags by zero-order controlled release kinetics. As discussed in Chapter 1 (Section 1.5.1), zero-order controlled release offers the advantages of ... 

Peppas N. Mathematical models for controlled release kinetics. In Danger RS and Wise DL, eds. Medical Application of Controlled Release, Vol. I. Boca Raton, FL CRC Press, 1984, p. 169. 

Rhine, W.D., D.S.T. Hsieh, and R. Langer, Polymers for sustained macromolecular release procedures to fabricate reproducible delivery systems and control release kinetics. Journal of Pharmaceutical Science, 1980, 69, 265-270. 

P Lecome, JH Rytting, V Cajan, F Chevanne. R Laverge. In-vitro controlled release kinetics of local anesthetics from poly(D.L-laciide) and poly(lactide-co-glycolide) raiero.spheres. J. Microencapsulation 14 243-255. 1997. 

The development of peptides and proteins as commercially viable therapeutic agents has presented some unique challenges to the drug delivery scientist. Areas where expanded research efforts are important include development of delivery systems with precisely controlled release kinetics—with a particular emphasis on a fundamental understanding of the mechanism of drug release (Shah et ah, 1992) —and further development of pulsatile (e.g., for vaccine delivery), and temporal release systems where the release of drug is consistent with the biochemistry of the disease state. 

In the following sections, we describe research regarding the dehvery of proteins, including model proteins, enzymes, hormones, growth factors, and cytokines, from the atrigel system. (A listing of the proteins studied in this system is presented in Table I). The methods ofprotein analysis and the factors used to control release kinetics are summarized. In addition, in vitro and in vivo systems employed to determine bioactivity of protein formulations are presented. The imphcations regarding the controlled dehvery of proteins are discussed. 

Rhine, W. D., Hsieh, D. S. T., and Langer, R., 1980a, Polymers for sustained macromolecule release Procedures to fabricate reproducible delivery systems and control release kinetics, J. Pham. Sci. 69 265-270. 

Fan DM, Loni A, Canham LT, Coffer JL (2009) Location-dependent controlled release kinetics of model hydrophobic compounds from mesoporous silicon/biopolymer composite fibers. Phys Status Solidi A 206 1322... 

Javierre E., Garda S.J., Mol J.M.C., Vermolen F.J., Vmk C., van der Zwaag S. (2012), TaUoiing the release of encapsulated corrosion inhibitors from damaged coatings controlled release kinetics by overlapping diffusion fronts . Prog. Org. Coat. 75,20-27. 

A thickening coemulsifier can be added to the external water phase of W/ OAV multiple emulsions. The optimized emulsifier-coemulsifier pair at the interface will lead to improved packing, elasticity, and temperature stabihty of the final multiple emulsion. Furthermore more controlled release kinetics of release can be achieved (Terrisse et al, 1994). 

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