Controlled release classification

The dissolution controlled release matrix systems provide sustained release profiles i.e., the active drugs in these systems are released continuously at a slow rate to provide a long-term therapeutic effect. Unlike diffusion controlled release coated systems, release profiles from dissolution controlled release coated systems do not follow zero-order kinetics but fall within the classification of delayed release systems,4 pulsatile or repeat-action systems,5 and sustained release systems.3... [Pg.140]

Classification of Controlled-Release Drug Delivery Systems. [Pg.4]

A useful classification of controlled-release polymeric system based on the mechanism controlling the drug release is as follows ... [Pg.4]

Figure 5.2 Classification of controlled release systems (HeUer, 2012).

Tayout also has a significant role in minimizing the probability of ignition of a flammable release. Area electrical classification provides the basis for the control of electrical ignition sources. This classification is also used to determine the areas that require protection from vehicular access, etc. Frequently, highly hazardous processes that can result in overpressure (e.g., hydrogenation) are placed behind blast resistant structures/walls. [Pg.27]

Ignition of flammable Provide safe separation distances release resulting in fire. Develop appropriate area electrical or explosion. classification Provide ignition source control Place ignition sources in positive pressure enclosure and buildings Provide adequate ventilation API RP500 BS 5345 BS 5958 NFPA-70 NFPA-77... [Pg.31]

However, in the foregoing systems, the predominant mechanism allows easy mathematical description. In practice, the dominant mechanism for release will overshadow other processes enough to allow classification as either dissolution rate-limited or diffusion-controlled. Bioerodible devices, however, constitute a group of systems for which mathematical descriptions of release characteristics can be quite complex. Characteristics of this type of system are listed in Table 7. A typical system is shown in Fig. 8. The mechanism of release from simple erodible slabs, cylinders, and spheres has been described [36], A simple expression describing release from all three of these erodible devices is... [Pg.513]

PEL Pg pmol PHS PMR ppb ppm ppt REL RfD RTECS sec SCE SIC SIR SMR STEL STORET TLV TSCA TRI TRS TWA u.s. UF yr WHO wk permissible exposure limit picogram picomole Public Health Service proportionate mortality ratio parts per billion parts per million parts per trillion recommended exposure limit Reference Dose Registry of Toxic Effects of Chemical Substances second sister chromatid exchange Standard Industrial Classification Standardized incidence ratio standard mortality ratio short term exposure limit STORAGE and RETRIEVAL threshold limit value Toxic Substances Control Act Toxics Release Inventory total reduced sulfur time-weighted average United States uncertainty factor year World Health Organization week... [Pg.228]