Controlled release aspirin tablets

Aspirin is commercially available in numerous formulations (Table 7-1). It is compounded as a tablet, an enteric-coated tablet, a controlled-release tablet, and as a suppository. Enteric-coated aspirin, which decreases GI tract irritation, is recommended for chronic use but is rarely required for the treatment of acute ocular pain, which usually resolves over several days. Likewise, controlled-release aspirin, because of its relatively long onset of action, is not recommended for treatment of acute ocular pain. 

Heng, P. W., Chan, L. W., Easterbrook, M. G., and Li, X. (2001), Investigation of the influence of mean HPMC particle size and number of polymer particles on the release of aspirin from swellable hydrophilic matrix tablets, J. Controlled Release, 76, 39-49. 

Ibric, S. Jovanivic, M. Djuric, Z. Parjcic J. Solomun, L. The application of a generalized regression neural network in the modelling and optimization of aspirin extended release tablets with Eudragit RSPO as matrix substance. J. Controlled Release 2002, 82, 213-222. 

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