Contiguous gene

Operon. A group of contiguous genes that are coordinately regulated by two cis-acting elements A promoter and an operator. Found only in prokaryotic cells. 

MC148R is a contiguous gene, typical of poxviruses, lacking introns. 

Bobrowicz, P., Wysocki, R., Owsianik, G., Goffeau, A., and Ulaszewski, S. (1997) Isolation of three contiguous genes, ACRl, ACR2 and ACRB, involved in resistance to arsenic compounds in the yeast Saccharomyces cerevisiae. Yeast, 13, 819-828. 

The answer is e. (Murray, pp 787—811. Scriver, pp 521-529. Sack, pp 85—96. Wilson, pp 187—229.) Contiguous gene syndromes, also known as microdeletion syndromes, occur when deletions result in the loss of several different closely linked loci. Depending on the size of the deletion, different phenotypes may result. Mutations in the individual genes may result in isolated features that may be inherited in a Mendelian fashion. 

Aspergillus nidulans npeA locus consists of three contiguous genes required for penicillin biosynthesis, EMBOJ., 1990, 9, 279-287. 

Nepal implements 3 different mutation operators speed-up, slow-down and random. Mutation applies on N randomly selected between 1 and N and the gene list is considered circular. 

Martignoni G, Bonetti F, Pea M, et al. Renal disease in adults with TSC2/PKD1 contiguous gene syndrome. Am J Surg Pathol 2002 26(2) 198-205. 

Nseir G, Golshayan D, Barbey F. Phenytoin-associated severe hypocalcemia with seizures in a patient with a TSC2-PKD1 contiguous gene syndrome. Ren Fail July 2013 35(6) 866-8. 

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