Secondary contaminations

The principal disadvantage of this procedure resides in its application to terminal olefins. Since the hydroboration step produces ca. 94% primary boron-bound alkyl groups, the maximum purity of primary carbinol is obviously limited to ca. 94%. Isolation of primary alcohol free of the contaminant secondary alcohol requires a tedious, yield-lowering fractionation procedure. This difficulty may be circumvented by employing a more selective hydroborating reagent, disiamylborane, as illustrated in the synthesis of 1-octanol. 

BGCAPP Projected IX Agent-Contaminated Secondary Waste Generation Rates During Operations and Closure, 29... 

TABLE 4-7 PCAPP Projected Amounts of Mustard-Agent-Contaminated Secondary Waste from Normal Operations According to Level of Agent Contamination... 

Following approach 1, if <1.0 VSL, the waste is classified as clean and shipped offsite, and if >1.0 VSL, approach 2 or approach 3 is followed (PMACWA. 2006). Adequate decontamination, defined as <1.0 VSL, may need to be accomplished in the SDU or the autoclave and verified via monitoring at the SDU or the autoclave. As previously indicated, Table 4-6 shows the total estimated secondary wastes, while Tables 4-7 and 4-8 show projected generated quantities of contaminated secondary wastes according to their level of contamination (before any onsite treatment) for the operational and closure stages of PCAPP, respectively. 

Recently, CMA issued guidance on factors that must be considered and addressed for offsite shipment of agent-contaminated secondary waste. The guidance states as follows ... 

The Gabriel synthesis has great utility in that it produces pure primary amines (such as "C"), free from contaminating secondary or tertiary amines. 

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