Container breakage

Chemicals likely to enter into violent reactions should not be stored close together, since there is always a possiblity of container breakage. 

Liquid formulations account for about 30% of products in the UK market and, because they are easy to swallow, are favoured for paediatric and geriatric use. An aqueous solution is the simplest formulation to produce, but more complex suspensions or emulsion systems will be required if the drug is poorly soluble. Liquid formulations can be administered by all routes and are probably the most versatile systems. Liquids are, however, bulky, difficult to transport and container breakage can result in catastrophic loss. 

Crimping is the act of securing the closure to the vial. It must be performed with sufficient uniform downward force to assure the container is properly secured. Too little downward force results in inadequately secured closures, while excessive force can result in container breakage. The force contributed by the crimp roller may be controllable as well. 

The result of product freezing and thawing is internal pressure generation. If the container is overfilled, excessive pressure can result with subsequent container breakage. Fills of less than 50% of the container volume are recommended, with an optimum of about 35%. 

Basic resins and curing agents for thermosetting adhesives should be kept apart so that accidental container breakage will not lead to contamination problems. Containers for solvent-based adhesives should generally by sealed immediately after use to prevent solvent loss and the emission of toxic or flammable vapors. ... 

Container breakage and miscellaneous consequences of product freezing... 

Basic resins and curing agents for thermosetting adhesives should be kept apart so that accidental container breakage will not lead to contamination... 

Polystyrene (PS). Common appHcations include packaging, food containers, and disposable tableware toys furniture, appHances, television cabinets, and sports goods and audio and video cassettes. For some of these appHcations, PS is modified by blending or graft polymerization with SBR to form impact polystyrene, which is less sensitive to breakage. Expandable polystyrene is widely used in constmction for thermal insulation. 

For a steady-state ciystallizer receiving sohds-free feed and containing a well-mixed suspension of ciystals experiencing neghgible breakage, a material-balance statement degenerates to a particle balance (the Randolph-Larson general-population balance) in turn, it simplifies to... 

Many flammable liquids are used for a variety of purposes in bench work, either in semi-closed containers or in open trays. If spillage occurs due to breakage of apparatus or plant, or carelessness in handling, the liquid is distributed over a large area and considerable vapor is produced. Fires due to the ignition of vapors spread with extreme rapidity over the exposed surface of the liquid and the amount of flame and heat given off quickly increases. 

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