Constipation drug-related

On the other hand, constipation may occur in some patients receiving tube feedings, especially the elderly. Increased provision of fluid or fiber may be useful in attaining bowel regularity. As with diarrhea, constipation maybe drug-related, in which case discontinuation or replacement of the offending drug may help to alleviate the problem. 

Acs, N., F. Banhidy, E.H. Puho, and A.E. Czeizel. 2010. No association between severe constipation with related drug treatment in pregnant women and congenital abnormalities in their offspring A jxjpulation based case control study. Congen. Anom. 50 (l) 15-20. 

Placebo-controlled studies The efficacy and safety of prucalopride 2 or 4 mg/day for 12 weeks has been assessed in a double-blind, placebo-controlled trial in patients with severe chronic constipation [15 ]. The most common drug-related adverse events included headache, abdominal pain, nausea, and diarrhea (which occurred mainly on day 1 of treatment). However, there were no differences in the incidences of serious adverse effects or cardiovascular events compared with placebo. 

In a double-blind, randomized, placebo-controlled trial of prucalopride 2 or 4 mg/day for 12 weeks in 716 patients with chronic constipation, the most common drug-related adverse events were headache, nausea, abdominal pain, and diarrhea [16 "]. The overall incidence of prolongation of the QT interval was low and similar among all treatment groups. Withdrawals as a result of these adverse events accounted for a higher dropout rate in those who took prucalopride 4 mg/day (15%), than in the other treatment groups (6.3% and 6.7% with 2 mg/day and placebo respectively). 

Constipation related to adverse drug etfeds (aluminum- or calaum-containing ant adds)... 

The side-effect profile of duloxetine is similar to that of SSRIs. Like the SSRIs, duloxetine does not affect cardiac conduction or lower the seizure threshold. In most patients, duloxetine is not associated with sedation. Side effects that differ from those of SSRIs are hypothesized to be related to the increased noradrenergic activity of this drug and include dry mouth, constipation, and increased sweating. 

CNS side effects include confusion, anxiety, lethargy, nausea and vomiting. GIT related effect is constipation. Other side effects are urinary retention, dry mouth, miosis, dysphoria, hypotension, skin rash, itching and urticaria. Tolerance, drug dependence and drug abuse are the main drawbacks of morphine. 

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