Consolidated risk assessment report

Following risk evaluation, a consolidated risk assessment report is prepared, covering the description of the site and the pollutant linkages identified and the overall risk assessment, supported by validated data sets. This sets out unambiguously the main risks posed by the site and whether these are acceptable or not, and may identify preliminary options for dealing with unacceptable risks. 

The Nuclear Engineering Institute (NEI) issued the report NEI (1996). This document is a guideline for applying the Maintenance Rule to Nuclear Power Plants. Section 11.0 of NEI (1996) consolidates the assessment and management of the increase in risk that may result from the proposed maintenance activities. 

With relevance to the administration of thiopurines in the early course of childhood ALL, the BFM Study Group reported on the association of TPMT genotype and minimal residual disease (MRD) in 810 children with childhood ALL enrolled into their trial ALL-BFM 2000 (206). In this trial, DNA-based MRD analysis after induction and after consolidation treatment was used for risk-adapted treatment stratification. A 4-week cycle of 6-MP was applied in-between these two MRD measurements. In patients homozygous for the TPMT 1 allele or those heterozygous for a variant TPMT allele, MRD levels on treatment day 33 were equally distributed between the groups. However, when MRD levels were assessed on treatment day 78, after administration of consolidation... 

---

See also in sourсe #XX -- [ ]

---