Conjugation of proteins

N. Katre, The conjugation of proteins with polyethylene glycol and other polymers. Altering properties of proteins to enhance their therapeutic potential. Advances Drug Del. Rev, 10, 91 (1993). 

Akagi T, Kaneko T, Kida T et al (2006) Multifunctional conjugation of proteins on/into coreshell type nanoparticles prepared by amphiphilic poly(y-glutamic acid). J Biomater Sci Polym Ed 17 875-892... 

Some reports even indicate that the conjugation of proteins or peptides with carbohydrates can increase dramatically their activity compared to that of the native state (Susaki et al., 1998). Carbohydrates also can provide a protective effect on modified peptides toward proteolytic digestion (Rudd et al., 1994) or mask recognition of a peptide by the immune system (Harding et al., 1993). The creation of neoglycoproteins thus can affect the activity of peptides and proteins, which are not normally glycosylated in vivo. 

Lamture, J.B., and Wensel, T.G. (1995) Intensely luminescent immunoreactive conjugates of proteins and dipicolinate-based polymeric Tb (III) chelates. Bioconjug Chem 6(1), 88-92. 

Liu, F.-T., Zinnecker, M., Hamaoka, T., and Katz, D.H. (1979) New procedures for preparation and isolation of conjugates of proteins and a synthetic copolymer of D-amino acids and immunochemical characterization of such conjugates. Biochemistry 18, 690-697. 

Mumtaz, S., and Bachhawat, B.K. (1991) Conjugation of proteins and enzymes with hydrophilic polymers and their applications. Indian J. Biochem. Biophys. 28, 346-351. 

I. A. Proposed role of ATP in protein breakdown conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis. 

Hershko, A., Ciechanover, A., Heller, H., Haas, A. L. and Rose, 1. A. (1980). Proposed role of ATP in protein breakdown Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis. Proc.Natl. Acad. Sci. USA 77, 1783-1786. 

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