Conjugated poly block

Yokoyama, M., Miyauchi, M., Yamada, N., Okano, T., Sakurai, Y, Kataoka, K., and Inoue, S. Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. Cancer Res., 1990, 50, 1693-1700. 

Yokoyama, M., M. Miyauchi, N. Yamada, T. Okano, Y. Sakurai, K. Kataoda, and S. Inoue. 1990. Polymer micelles as novel carrier adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymerJ. Control. Rel.11 269-278. 

Micellar systems based on amphipathic block-copolymers have gained most attention as intravenously administered drug carrier systems over the years. These block-copolymers are composed of a hydrophilic PEG block and a hydrophobic block based on doxorubicin conjugated poly(aspartic acid) or poly(/i-bcnzyl L-aspartate). 

Yokoyama M, Inoue S, Kataoka K, Yui N, Sakurai Y. Preparation of adriamycin-conjugated poly(ethylene glycol)-poly-(aspartic acid) block copolymer. A new type of polymeric anticancer agent. Makromolekul Chemi Rapid Commun 1987 8 431-435. 

Huang and coworkers [437] reported preparation of a series of well-defined amphiphilic block copolymers containing conjugated poly(fluorene) (PF) block and coil like poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA). The block copolymers were synthesized through ATRP. The reactions were initiated by a 2-bromoisobutyrate end-capped macroinitiator using CuCl/ 1,1,4,7,10,10-hexamethyltriethylenetetramine as the catalyst. 

Figure 15 Schematic representation of the self-assembly of pH-sensitive drug-loaded micelles which was synthesized from drug conjugated amphiphilic block copolymers, that is, polyfethylene glycol)-poly(aspartate-hydrazone-adriamycin) (PEG-p(Asp-Hyd-ADR)). (Reproduced from Ref. 92. Wiley-VCH, 2004.)...

Yokoyama, M., Inoue, S., Kataoka, K, et al. (1987) Preparation Of Adriamycin-Conjugated Poly(Ethylene Glycol)-Poly(Aspartic Add) Block Copolymer - A New Type Of Polymeric... 

A large part of organic and macromolecular chemistry starts with the chemical functionalization of benzene, and benzene units serve us building blocks for important polymers. Naturally, benzene-based aromatic materials also represent an important subclass of jt-conjugaled architectures. Despite some synthetic difficulties related to the generation of structurally well-defined oligo- and poly(phenyl-... 

The versatility of poly(phenylcne) chemistry can also be seen in that it constitutes a platform for the design of other conjugated polymers with aromatic building blocks. Thus, one can proceed from 1,4- to 1,3-, and 1,2-phenylene compounds, and the benzene block can also be replaced by other aromatic cores such as naphthalene or anthracene, helerocyclcs such as thiophene or pyridine as well as by their substituted or bridged derivatives. Conceptually, poly(pheny ene)s can also be regarded as the parent structure of a series of related polymers which arc obtained not by linking the phenylene units directly, but by incorporation of other conjugated, e.g. olefinic or acetylenic, moieties. 

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