Conformational Heterogeneity in Translesion Synthesis

Conformational heterogeneity at the replication fork can dictate the dynamics of protein-DNA interactions in the active site pocket of a polymerase, thus affecting 

Differential scanning calorimetry (DSC) experiments were utilized to examine the thermodynamic contribution of AF heterogeneity on replication fidelity [79]. Unlike the UV-based data, DSC-derived thermodynamic data are model- 

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