Conclusions and practical applications

Epidemiological studies suggest that phthalate plasticizers m possess adjirvant effect and, thus, may promote development of allergic airway diseases. Recent studies in arri-mals demonstrated that several of the commonly used phthalate plasticizers were adjuvants although their potentials as adjrrvants varied. The adjuvant effect observed in the animal studies occttrred with concentratiorrs which were at the same levels as observed for 

Health and Safety Issues with Plasticizers and Plasticized Materials 

As the adjuvant effect varied with the chemical stracture of the phthalates, this suggests that plasticizers with appropriate technical properties but without adjuvant effect may be developed. 

This study has been produced as part of the research activities in the Centre for the Environment and Respiratory System, which is supported by the Danish Environmental Research Program. 

Fujimaki H, Saneyoshi K, Shiraishi F, Imai T, Endo T, Toxicology, 116, 227-233 (1997). 

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