Conclusions and Perspectives Whats the Next Step

As many chapters in this book and recent reviews [4-6, 27,110] indicate, substantial progresses are being made in the QM/MM community for both DFT/ab initio and SE based QM/MM methods. For relatively localized chemical reactions, very reliable 

We thank the contributions of many group members, especially Drs. D. Riccardi and P. Koenig, without whom the work discussed here could not have been done. The studies were partially supported from the ACS-PRF-38186-G4, National Science Foundation (MCB-0314327,CHEM-CAREER-0348649) and the National Institutes of Health (R01-GM071428-01). Q.C. also acknowledges a Alfred P. Sloan Research Fellowship and discussions with Prof. D. M. York on many QM/MM related topics. Computational resources from the National Center for Supercomputing Applications at the University of Illinois are greatly appreciated. 

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