Concentrate processing packaging techniques

This strategy is adopted because of the sheer complexity of the process and the unavailability in the past of suitable sensors for on-line quality moisture content measurement. The quality of the product such as final moisture content, thickness, porosity, wetting, and rehydration capability (for pregelatinized starch) as well as the right crystal structure (the right therapeutic form for pharmaceuticals) are complex functions of drum speed, temperature, nip width, feed material, feed concentration, and feedspreading technique. In addition, the final moisture content and thickness of the sheet may not be uniform across the width of the drum dryer that can lead to problems in shelf life and packaging of the product, respectively. 

The BioView sensor includes a software package (CAMO ASA, Norway) for data analysis and on-Une estimation of different bioprocess variables simultaneously. Thus, the instrument is able to predict the trends of the concentration courses of different variables during a cultivation and is used to give information about important process steps (e.g., feeding time, harvesting time, etc.). The instrument is able to monitor on-line several fluorophores in situ and non-invasively during cultivation processes and permits an estimation of different bioprocess variables simultaneously. The increasing of cell mass concentration and the product formation as well as the actual metabolic state of the cells is simultaneously detectable by this fluorescence technique. 

A recent shift toward the discovery and development of new chemical entities that have greater potency has required their dosing at lower levels popular sample-preparation techniques such as protein precipitation are less useful for analyte concentrations below 1 ng/mL. Additionally, the frequent use of mouse plasma necessitates the use of sample volumes <50 pL and effectively miniaturizes the sample-preparation process. In these situations, SPE is especially appealing due to packaging of sorbents within small-diameter, thin disks requiring dramatically lower solvent and elution volumes [54,78-80]. Also, the benefits of disks are often attainable with small sorbent bed masses packed in colunms that are now available in bed masses as low as 2 mg [81]. 

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