Retrosynthetic analysis computer assisted

Functional Group Interconversion. Show how each of the following compounds can be prepared from the given starting material. 

Retrosynthetic Analysis — One-Step Disconnections. For each of the following compounds, suggest a one-step disconnection. Use FGIs as needed. Show charge patterns, the synthons, and the corresponding synthetic equivalents. 

Synthesis, Outline a retrosynthetic scheme for each of the following target molecules using the indicated starting material. Show (1) the analysis (including FGI, synthons, synthetic equivalents) and (2) the synthesis of each TM. 

(a) Warren, S. Organic Synthesis The Disconnection Approach, Wiley New York, 1982. (b) Corey, E. J., Cheng, X.-M. The Logic of Chemical Synthesis, Wiley New York, 1989. 

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The computer-assisted synthetic analysis designated OCSS (organic chemical simulation of synthesis) and LHASA (logic and heuristics applied to synthetic analysis) were designed to assist chemists in synthetic analysis by Corey et LHASA generates trees of synthetic intermediates from a target molecule by analysis in the retrosynthetic direction. 

Retrosynthetic Analysis. An approach to computer-assisted synthesis design that starts with the products of a reaction or sequence of reactions and works backwards toward the reactants. An example program that implements retrosynthetic analysis is the LHASA program of E. J. Corey s group. 

There are a number of computer programs which can assist the synthetic chemist in the retrosynthetic analysis of a target compound. One that is specifically designed to be applied to the synthesis of chiral compounds is the CHIRON program, developed at the University of Montreal by Professor Steve Hanessian. CHIRON does not generate a full retrosynthetic tree but rather yields readily available starting materials from the Chiral Poof that contain the chirality needed to construct the product in optically pure form. 

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