Compound Half-life and Clearance

TABLE 3.2 Sorption Parameters for Six Commonly Encountered Pharmaceuticals in Two Soils and with Sludge Digested Under Distinctly Different Conditions  

Solubihty values were compiled from Kasim et al. (2004) and for clofibric acid from Embhdge and DeLorenzo (2(X)6). 

In clinical settings, kg is influenced by drug clearance (CL) and the volume of distribution (F) based on the relationship in Eq. (3.22)  

Clearance in this instance relates the concentration of the dmg in blood to the rate at which it is eliminated from that system. It represents the volume of blood that is irreversibly cleared of the compound per unit time. The volume of distribution (F) is the amount of drug in the body per unit concentration in the blood, that is, 

Amount of drug in the body Drug concentration in the blood 

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