Compound aminobenzene

Heavily fluonnated aminobenzenes, pyridines, and pyrimidines are diazotized in strong-acid media Solid sodium nitrite added directly to the fluonnated amine dissolved in 80% hydrofluonc acid, anhydrous hydrogen fluoride, or (1 1 wt/wt) 98% sulfuric acid in (86 14 wt/wt) acetic and propionic acids affords the electrophilic fluoroarenediazonium ion Addition of an electron rich aromatic to the resultant diazonium solution gives the fluoroareneazo compound [10 II] (equa tions 9 and 10)... 

Xmino-benzol, n. aminobenzene, aniline, -essig-siure,/. aminoacetic acid, glycine, -kohlen-saure, /. amidocarbonic acid, carbamic acid, sfiure, /. amino acid, -saurerest, m. amino acid residue, -verbindung, /. amino compound. -zucker, m. amino sugar. 

By heating the diacetyl compound with sodium hydroxide solution partial saponification of the acetyl groups takes place. 25.6 grams of diacetyl compound are heated to boiling for some hours with 100 cc of 2 N sodium hydroxide solution. The precipitate produced by acidification of the solution with acetic acid is filtered off and treated with dilute sodium carbonate solution. The 4-aminobenzene-sulfonacetylamide passes into solution while the simultaneously formed 4-acetylaminobenzene-sulfonamide remains undissolved. It is filtered with suction and the filtrate again acidified with acetic acid. The 4-aminobenzene-sulfon-acetamide separates out and is recrystallized from water. It forms colorless lustrous rhombic crystals Of MP 1B1°C. 

Aniline (aminobenzene) is an oily liquid that turns brown when exposed to air and light. The compound is an important dye precursor. 

The monomer of the conducting polymer polyaniline is the compound aniline (aminobenzene). (a) Draw the structural formula of the aniline monomer. What is the hybridization of the N atom in (b) aniline (c) polyaniline (d) Indicate the locations of lone pairs, if any, in polyaniline, (e) Do the N atoms help to carry the current Explain your reasoning. See Box 19.1. 

The mode of action of sulfanilamides became known around 1947, when the structure and biosynthesis of folic acid were elucidated. This compound is built by bacteria from the heterocyclic pteroyl moiety, p-aminobenzoate, and glutamate. p-Aminobenzene-sulfonamide (9.89, sulfanilamide) is a competitive inhibitor of the synthase enzyme, acting as an antimetabolite of p-aminobenzoate. Occasionally, the sulfanilamide can even be incorporated into the modified folate, resulting in an inactive compound and thus an inactive enzyme. This theory, proposed by Woods and Fildes in 1940, became the first molecular explanation of drug action. 

The indole 1211 was converted to quinone 1212 by a convenient procedure involving reduction to the indoline followed by Fremy oxidation (Scheme 233) <1998B15199>. The indoline is an aminobenzene derivative, a class of compounds known to undergo Fremy oxidations readily. The Fremy s salt also converts the indoline back to the indole resulting in quinone 1212 as the final product. Aziridination of quinone 1212 to afford compound 1213 was carried out with aziridine under aerobic conditions (reductive addition of aziridine followed by air oxidation to the quinone). 

Aromatic substances, more than any other class of organic compounds, have acquired a large number of nonsystematic names. The use of such names is discouraged, but lUPAC rules allow for some of the more widely used ones to be retained (Table 15.1). rhus, methylbenzene is known commonly as toluene hydroxy benzene, as phenol aminobenzene, as aniline and so on. 

Cyclodehydration of 2-hydroxy- or 2-aminobenzene-ethanal derivatives is known as a general procedure for the synthesis of benzo-fused heteroaromatic compounds [95]. Although numerous modifications of this general method have been explored, the major difficulty seems to be the lack of a general method for the synthesis of the required ortho-functionalized arene-ethanals. 

It has been found possible to construct the 1,4-benzothiazine ring by direct interaction of bis-(2-aminobenzene) disulfide (96) with carbonyl compounds.139,140 The reaction is most efficient when conducted under a nitrogen atmosphere with a 1 1 ratio of reactants otherwise, the principle products are benzothiazoles. While reduction of the benzothiazine 97 with sodium borohydride gives a stable dihydro derivative, the unsaturated benzothiazines themselves were prone to autoxidation, giving rise to benzothiazoles and benzothiazine sulfoxides.141... 

The classic case is that of Prontosil (Figure 7.1) in which the compound is active against bacterial infection in animals although inactive against the bacteria in pure culture. The toxicity in animals is the result of reduction to the sulfanilamide (4-aminobenzene-sulfonamide) that competitively blocks the incorporation of 4-ami-nobenzoate into the vitamin folic acid. 

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