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Complexation with platelet factor

The protein-C pathway is one of the most important anticoagulant mechanisms. It is activated by thrombin. Thrombin binds to a cofactor in the membrane of endothelial cells, thrombomodulin (TM). TM bound thrombin no longer activates clotting factors or platelets but becomes an effective protein C (PC) activator. Activated PC (APC) forms a complex with Protein S, which inactivates FVIIIa and FVa. Hereby generation of Flla by the prothrombinase complex is inhibited (Fig. 9). Thus, the PC-pathway controls thrombin generation in a negative feedback manner. [Pg.379]

Stuckey JA, St Charles R, Edwards BF. A model of the platelet factor 4 complex with heparin. Proteins 1992 14 277-87. [Pg.30]

Sultan Y Loyer F In vitro evaluation of factor VI11-bypassing activity of activated prothrombin complex concentrates and factor Vila in the plasma of patients with factor VIII inhibitors thrombin generation test in the presence of collagen-activated platelets. J Lab Clin Med 1993 121 444-452. [Pg.28]

It is now widely accepted that atherosclerosis is a chronic inflammatory arterial disease associated with risk factors, platelet, and other blood cells activities and their interactions with subendothelial cells, Activated platelets release active components from citosol and induce the externalization of phosphatidylserine through the flip-flop mechanism (23) that supports the function of the prothrombinase complex ending in thrombin generation,... [Pg.37]

GralnickHR,V anisSB, CollerB. Fibrinogen competes with von Willebrand factor for binding to the Glycoiantein Ilb /Ilia complex when platelets are stimulated with thrombia Blood 1984 64 797-800. [Pg.339]

See other pages where Complexation with platelet factor is mentioned: [Pg.51]    [Pg.124]    [Pg.51]    [Pg.124]    [Pg.51]    [Pg.124]    [Pg.51]    [Pg.124]    [Pg.237]    [Pg.1885]    [Pg.93]    [Pg.954]    [Pg.830]    [Pg.108]    [Pg.112]    [Pg.601]    [Pg.16]    [Pg.124]    [Pg.76]    [Pg.134]    [Pg.335]    [Pg.298]    [Pg.181]    [Pg.457]    [Pg.719]    [Pg.366]    [Pg.258]    [Pg.247]    [Pg.633]    [Pg.245]    [Pg.118]    [Pg.270]    [Pg.7]    [Pg.261]    [Pg.766]    [Pg.253]    [Pg.2]    [Pg.11]    [Pg.35]    [Pg.36]    [Pg.290]    [Pg.108]    [Pg.112]    [Pg.329]    [Pg.210]    [Pg.354]    [Pg.13]   
See also in sourсe #XX -- [ Pg.4 , Pg.43 , Pg.124 ]



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Platelet Factor 4, complexes with heparin

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