Complexation with ethylenediaminetetraacetic acid

Fuger, J. (1958). Ion exchange behavior and dissociation constants of americium, curium and californium complexes with ethylenediaminetetraacetic acid, J. Inorg. Nucl. Chem. 5, 332. 

The only compounds with this type of ligand appear to be the hydrated neptunium(V) complexes with ethylenediaminetetraacetic acid (H4edta), (Np02)2H2(edta)-5H20 and [Co(NH3)6]Np02(edta) -3H20. 

The most important ferrous developers, however, are the complexes with ethylenediaminetetraacetic acid (EDTA) and related ligands, such as diethylenetriaminepentaacetic add (DTPA), nitrilotriacetic add (NT A) and JV-hydroxyethylethylenediaminetriacetic add (HETA). Complexes... 

The first chelating resins that were found to be really suitable for application in the field of selective cation absorption were those based on the aminodiacetate functional group.380 The first commercial resin based on this functional group, Dowex Al, was shown381 to have an affinity for a range of metals which was similar to the order of dissociation constants of the metal complexes with ethylenediaminetetraacetic acid (EDTA), i.e. 

A germanium complex with ethylenediaminetetraacetic acid (Hedta) 532 has a pen-tadentate edta ligand with one protonated acetate group which does not coordinate, forming a six-coordinate complex1150. 

Cauchetier, P., and Guichard, C. Electrochemical and spectro-photometric study of plutonium complexes with EDTA. Pluto-nium(V) and (VI), J. Inorg. Nucl. Chem., 1771 (1975). Kabanova, 0. L. Plutonium(V) complexes with ethylenediaminetetraacetic acid, Russ. J. Inorg. Chem., 401 (1961). 

P Kuban, P Kuban, V Kuban. Simultaneous capillary electrophoretic separation of small anions and cations after complexation with ethylenediaminetetraacetic acid. J Chromatogr A 836 75-80, 1999. 

Table 6.12 Mossbauer parameters for iron(III) complexes with ethylenediaminetetraacetic acid (H4EDTA) and diethylenetriaminepentaacetic acid (H5DTPA) [133-134]...

Yoshino, Y. Ouchi, A. Tsunoda, Y. Kojima, M. "Manganese(III) complexes with ethylenediaminetetraacetic acid", Canad. J. Chem. 1962, 40, 775-783. 

Wood and Higginson " have made a detailed study of the kinetics of oxidation of Fe(ll) by a number of complexes of Co(IIl) with ethylenediaminetetraacetic acid (H4Y = EDTA) and hydroxyethylethylenediaminetriacetic acid (H3YOH = HEDTA). Rate data and activation parameters are quoted (Table 21) for the... 

Another attempted synthesis of Tc(III)-EDTA and Tc(III)-HEDTA complexes (EDTA ethylenediaminetetraacetic acid HEDTA A -(2-hydroxy-methyl)ethylenediamine-N,AT, iV -triacetic acid) was carried out using [Tc(tu)6]3+ as the starting complex [40]. Technetium-EDTA complexes have been synthesized by the direct reduction of pertechnetate with a suitable reduc-tant in the presence of excess EDTA [41-43]. On addition of EDTA to the Tc(tu) + solution, the intensity of the absorption spectrum decreased with time and the solution color changed from reddish orange to light brown. An electrophoretic analysis for the Tc(III)-EDTA complex showed that more than 70%... 

The stability of some metal complexes is very large. For example, with ethylenediaminetetraacetic acid (EDTA,... 

Foreman, J. K., and Smith, T. D. The nature and stability of the complex ions formed by ter-, quadri-. and sexa-valent plutonium ions with ethylenediaminetetraacetic acid. Part I. pH titrations and ion exchange studies, J. Chem. Soc.,... 

Hydroxumie acids. Oxidation of N-trimethylsilylamtdes (I, prepared by the reaction of a secondary amide with hexamethyldisilazane) with the MoOvMMPT complex in methylene chloride at room temperature for several hours np to several days affords dioxomolybdenum complexes (2) in moderate yields (15-40%). The free hydroxamic acids (3) are Hbcrated by treatment of (2) with ethylenediaminetetraacetic acid (EDTA). 

The influence of the hydrating tendency of cations co-sorbed with lithium isotopes on an ion exchange column was investigated in a series of experiments summarized in Table I. As the heat of hydration of the co-sorbed cation increased, the isotopic separation factor increased (13). The nature of the anion in the solution phase had very little effect upon the separation factor. However, for systems involving complexes of lithium with ethylenediaminetetraacetic acid, there was a reversal of the isotope effect. That is, Li concentrated in the resin phase instead of the aqueous phase as it usually did in ion exchange resin systems. 

Many dithiocarbamate complexes of zinc, silver, cadmium or mercury improve emulsion stability, including bis(dibenzyldithiocarbamato)-zinc(II) or -cadmium(II) and silver(I) diethyldi-thiocarbamate. Cadmium salts, mixed with citric acid or tartaric acid and added to the emulsion, are reported to be effective. Mercury(II) complexes of ethylenediaminetetraacetic acid (EDTA) and related ligands and of solubilized thiols such as (4) can be used. Other coordination compounds reported include EDTA and related ligand complexes of Co and Mn, mixtures of Co salts with penicillamine (5) and macrocyclic complexes of Ag such as (6). The latter compounds may be used in diffusion transfer systems in which transferred maximum densities are stabilized. 

A further prerequisite for an indium complex to be useful for nuclear medicine applications is that it be resistant to exchange with the plasma protein transferrin. Indium binds to transferrin at the Fe binding site with a stability constant (/f ) of lO in the presence of bicarbonate [7]. The formation constants of indium with ethylenediaminetetraacetic acid (EDTA) (log = 25.0) and DTPA (log Ki = 29.0) are such that at infinite dilution equilibrium would favor the formation of indium transferrin [8J. The slow dissociation of indium from these complexes hinders the formation of indium transferrin. 

---