Complementary molecular reactivity

Scheme 2.28 Complementary molecular reactivity and molecular recognition for library purification.

Parlow J. J. Flynn, D. L. Solution-Phase Parallel Synthesis of a Benzoxaz-inone Library Using Complementary Molecular Reactivity and Molecular Recognition (CMR/R) Purification Technology, Tetrahedron 1998,54,4013. 

The selected example by Flynn et al. [133] presented some purification strategies based on complementary molecular reactivity, molecular recognition, artificially imparted molecular recognition and solid support reaction quenching. All these concepts were exemplified by real applications and the first is reported in Figure 7.16. 

Flynn DL, Crich JZ, Devraj RV, Hockerman SL, Parlow JJ, South MS, Woodard S, Chemical library purification strategies based on principles of complementary molecular reactivity and molecular recognition, J. Am. Chem. Soc., 119 4874 1881, 1997. 

Parlow JJ, Mischke DA, Woodard SS, Utility of complementary molecular reactivity and molecular recognition (CMR/R) technology and... 

Flynn, D.L., Crich, J.Z., Devraj, R.V., Hockerman, S.L., Parlow, J.J., South, M.S. and Woodard, J. (1997) Chemical library purification strategies based on principles of complementary molecular reactivity... 

Parlow, J.J., Mischke, D.A. and Woodward, S.S., Utility of complementary molecular reactivity and molecular recognition CMR/R) technology and polymer supported reagents in solution-phase synthesis of heterocyclic carboxamides, J. Org. Chem., 62 (1997) 5908-5919. 

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