Complementarity determining regions function

Fig. 2. The location of silent mutations within Vn and VK segments. The position of silent nucleotide substitutions that have been observed in the functionally rearranged V genes expressed by hybridomas derived from immunized mice are indicated by an asterisk. Identity with the germ-line (or consensus) sequence is indicated by a dash. The location of complementarity determining regions (CDR) is indicated. The Vnll data represent the compilation of 3 independent Vn sequences, the VnOxl sequence represents 8 Vn sequences and the VKOxl sequence represents 5 sequences. (The VH11 data are taken from [93] and the VHOxl and V Oxl data are taken from references [100] and [101].)...

Relate the hypervariable sites of the H and L chains of IgG to the complementarity-determining regions (CDRs) of the immunoglobulin. Describe the function of the constant regions of the H and L chains of IgG. 

---