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Competitive glycosidase inhibitors

Polyhydroxylated piperidines from natural sources, which have structures and shapes resembling monosaccharides have been found as a -glycosidase inhibitors. They competitively inhibit glycosidases whose substrates they most closely resemble. 1-Deoxynojirimycin (moranoline) (98 1), was isolated from Mori Cortex (root bark of the mulberry tree, Morus bombycis (Moraceae)), leaves of Jacobinia suberecta (Acanthaceae)... [Pg.178]

QHijNOs, Mr 179.17, cryst., mp. 126-130°C, [ajo +63° (HjO final value). TTie amino sugar N. is present in the culture broths of various Streptomyces species (e. g., Streptomyces lavendulae). It exhibits very good antibacterial activity against Gram-positive bacteria. N. is a competitive inhibitor for specific glycosidases and simulates carbohydrate substrates (a- and jS-glu-cosidases). It is accessible by synthesis. ... [Pg.438]

Heck M-P, Vincent SP, Murray BW, Bellamy F, Wong C-H, Moskowski CJ (2004) Cyclic amidine sugars as transition-state analogue inhibitors of glycosidases potent competitive inhibitors of mannosidases. J Am Chem Soc 126 1971-1979... [Pg.113]

Diazirines (131) and (132), which are photolabile, are excellent competitive inhibitors of the corresponding glycosidases and can be used for photolabelling the enzymes. ... [Pg.45]

See other pages where Competitive glycosidase inhibitors is mentioned: [Pg.208]    [Pg.252]    [Pg.366]    [Pg.252]    [Pg.211]    [Pg.446]    [Pg.448]    [Pg.1626]    [Pg.67]    [Pg.43]    [Pg.203]    [Pg.242]    [Pg.198]    [Pg.198]    [Pg.418]    [Pg.1906]    [Pg.352]    [Pg.403]    [Pg.312]    [Pg.319]    [Pg.393]    [Pg.238]    [Pg.250]    [Pg.397]    [Pg.412]    [Pg.109]    [Pg.111]    [Pg.194]    [Pg.201]    [Pg.252]    [Pg.202]    [Pg.118]    [Pg.125]    [Pg.140]    [Pg.142]   
See also in sourсe #XX -- [ Pg.208 , Pg.209 , Pg.210 ]



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