Commercially Impregnated Chiralplates

Thin Layer Chromatography in Chiral Separations and Analysis 

FIGURE 3.2 Densitograms obtained in the quantitative determination of TLC-separated enantiomers of ferf-leucine (a) L-terf-leucine, (b) L-fe/t-leucine+0.1%D-tert-leucine, (c) L-tert-leucine + 1 % D-tert-leucine, and (d) external reference standard. Layer, Chiralplate mobile phase, methanol/water (10 80) detection, dip in 0.3% ninhydrin solution in acetone quantification, scanning at 520 nm. (Reprinted from Guenther, K. and Moeller, K., in Handbook of Thin Layer Chromatography, 3rd edn., Sherma, J. and Fried, B., Eds., Marcel Dekker, Inc., New York, NY, 2003, pp. 471-533. With permission.) 

The following selected applications were taken, with permission, from a Macherey-Nagel brochure [25] and the Applications Database on the Macherey-Nagel homepage (www.mn-net.com). The database search was carried out by choosing applications by phase, then TLC, and then Chiralplate. The application number from the database or reference to the brochure is cited in each case. 

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The preparation of CCSP plates was effected in the laboratory with the exception of commercially available Chiralplate (Macherey-Nagel) and HPTLC-Chir (Merck) constituted by silanized silica gel impregnated with the copper (II) complex of (25, 4R,2 7 5)-A-(2 -hydroxydodecyl)-4-hydroxyproline. These plates... 

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