Comments and Discussion

The requirement to use ecological risk assessment under the new contaminated land regulations will encourage practical and scientifically-based decision-making regarding the need for and scope of remedial action. This is to be welcomed since it will ensure that remediation will occur on the basis of risk, rather than hazard. 

The outcome of the Environment Agency s research on ecological risk assessment presents an approach which is similar to the many tiered systems that are already in existence. However, there is a lack of detail given on Tiers 2 and 3 and, as described above, the relationship of the GV-based approach to the requirements of the statutory guidance remains unclear. Subjects which were not covered, and which perhaps should have been, include the conversion of GVs between classes of organisms and the use of detailed wildlife risk assessment models (see, for example, Suter et al.s and US EPA6). 

Bamthouse, S. Bartelle, T. Mill, D. Mackay and S. Paterson, Ecological Risk Assessment, Lewis Publishers Inc., Chelsea, Michigan, USA, 1993. 

6 US EPA, Wildlife Exposure Factors Handbook, Office of Research and Development, Washington DC, USA, 1993. 

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The author has benefited greatly from discussions with Professors Karl Freeman, Evert Nieboer and Stephanie Atkinson on biochemistry and nntri-tion. Boaz Luz clarified my ideas about carbon isotope fractionation in blood. Research was supported by a grant from the Social Sciences and Humanities Research Council. The author thanks Shannon Coyston, Lori Wright, Chris White and Stanley Ambrose for useful comments and discussions. 

The author thanks Alan Winter (Glasgow) for critical comments and discussions regarding this chapter. This work is funded by the Medical Research Council through the award of an MRC Senior Fellowship. 

We thank Todd Sauke, Peter Watson, and (again) Colin Christy for pointing out the errors and for general comments and discussion. 

Dr. Nelly Blaes and Dr. Mogens Thomsen are thanked for helpful comments and discussions. 

Acknowledgement. The authors thank Drs. S. H. Jacobson and H. N. Sung for helpful comments and discussion. 

The authors gratefully acknowledge the help of Miss S. Mclver and Mr. J. Hutchinson in preparing the manuscript, and helpful comments and discussions with Dr. R. Stevens. This work was carried out during the tenure of a Senior Visiting Research Fellowship by S.P.H. at Sunderland Polytechnic, 1975-1976. 

The authors would like to thank Drs. Joseph J. Cooney and Laurence E. Hallas of the Chesapeake Biological Laboratory and Dr. Jon M. Bellama of the Department of Chemistry (all of the University of Maryland) for providing copies of unpublished manuscripts. The authors are indebted to Drs. Thomas D. Coyle, Warren P. Iverson, and Greg J. Olson, all of the National Bureau of Standards, for valuable comments and discussions. The authors also thank Dr. William H. Zoller (Department of Chemistry, University of Maryland) and Science magazine for granting copyright release. 

I hope that this book fulfils the expectations of its readers. I would finally like to thank many colleagues for fruitful comments and discussions on the manuscript, in particular, Dr Stephen J. Schaphorst and Maureen Storey, and Barbara Muller and Helga Muller for their help in preparing the book and last, but not least, my wife Annemarie and our daughters Verena and Sigune for their patience and understanding when I have spent much of my time in the preparation of this book. 

The author wishes to thank Dr. Higashi, Dr. Ujihira and Dr. Hiiro for valuable comments and discussions. 

Amendment in the light of comments and discussion at Committee session... 

The authors would like to acknowledge the editorial comments and discussions with Dr. Christopher Horvath of Archemix. In addition they would like to acknowledge Lori Cooper for her help in the preparation of this manuscript and Robert Saunders for his expertise with EndNote. 

The author is grateful to Dr. B. Honig, Dr. U. Dinur, and Dr. K. Schulten for valuable comments and discussions. Part of the work originating from this laboratory was carried out under the sponsorship of the Israeli Commission for Basic Research. 

Several workers have contributed to clarifying and otherwise improving the present article through their comments and discussion. I am indebted to Drs. Hans Poppe, J. J. Kirkland, M. Caude, and W. E. Hammers. These chromatographers have made a complicated story a bit easier to understand. 

Acknowlcdgementa. Thanks are given to Profs. J. Soria, G. Munuera and A. R. Gonzilez-Elipe for useful comments and discussions. Support Aom CICYT (Project Nr. MAT2000-1467) is also acknowledged. 

Thanks to K. C. McAuley for preparation of the figures and photographs and to V. A. Munoz and W. W. Lam, who contributed many of the photographs related to the optical and electron microscopy. Thanks are also due to C. K. Preston and J. C. Donini for the contribution on NIRA, C. A. Angle for the electrokinetic data, R. Zrobok for the rheology scans, and H. A. Hamza for useful comments and discussion on characterization technologies in general. 

The correlations that will be presented are based on the segmentation of the LV into two zones the anteroseptal and the inferolateral (Figure 1.14 and p. 17). The involvement of the anteroseptal zone corresponds to cases with occlusion of the LADand its branches (Table 4.1A),while the involvement of the inferolateral zone corresponds to the occlusion of the RCA and the LCX (Table 4. IB). We will study 12 different locations of coronary occlusions that define 12 areas at risk, 6 in the anteroseptal zone (Table 4.1 A) and 6 in the inferolateral zone (Table 4. IB). The ECG patterns that match with these different areas will be commented and discussed in all cases. 

The author would like to thank participants of two workshops held over the course of 2005 by the Fondazione Eni Enrico Mattei for valuable comments and discussion on a presentation that served as the background for this paper and the editors for comments on a draft version. The views expressed in this paper are those of the author and do not necessarily coincide with those of the European Commission. 

Each of the map series comprises a lot of detailed information. It is impossible to comment and discuss all of them. The complete set of maps is shown in the appended files on CD attached to this book. The reader is encouraged to have a look at these figures before going ahead in the text, which shall discuss some aspects based on a few selected examples. 

A procedure for identifying certain cholinesterase variants was proposed by Dietz et al. (D15). After a period during which comments and discussion were offered by others working in the field, the method was published in Selected Methods of Clinical Chemistry (D16). This method is based upon the Ellman reaction (ElO), which was used by Ellman et al. (Ell) for the assay of acetylcholinesterase, and by Garry and Routh (G9) for the assay of serum cholinesterase. In these assay procedures, a thiocholine ester is used as the substrate. The thiocholine produced upon hydrolysis reacts with 5,5 -dithiobis(2-nitrobenzoic acid) (DTNB) to yield 5-thio-2-nitrobenzoate anion and other products. The rate of the reaction may be determined by measuring the rate at which... 

We thank Ms A. Iglesias-Juez, Ms A.B. Hungrfa, Dr Z. Liu and Profs. J. Soria and G. Munuera for useful comments and discussions. Support from CICYT (Project MAT2000-1467), the EPSRC and the Royal Society (London) is gratefully acknowledged. 

The author thanks E.W. Maby and S.D. Senturia for their helpful comments and discussion and DuPont de Nemours and Company for providing the polyamic acid solutions. 

Wahlby, U., Jonsson, E.N., and Karlsson, M.O. Assessment of actual significance levels for covariate effects in NONMEM. Journal of Pharmacokinetics and Pharmacodynamics 2001 28 321-352. With comments and discussion given in 29 403-412. 

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