Combinatorial synthesis cation pool” method

The cation pool method serves as a powerful tool for parallel combinatorial synthesis.25 Required for successful combinatorial synthesis are reactions of high generality to couple any desired combination of molecules we want. The cation pool method seems to be suitable for this purpose, because organic cations generated by this method are usually so highly reactive as to couple with a wide range of nucleophiles. 

Figure 4. Parallel combinatorial synthesis based on the cation pool" method.

Combinatorial Synthesis Based on the Cation Pool Method... 

Figure 4.1 Parallel combinatorial synthesis based on the cation-pool method. (a) Schematic diagram (b) example based on the reaction of N-acyliminium ion pools with carbon nucleophiles...

The cation-pool method serves as a powerful tool for parallel combinatorial synthesis because of high reactivity of cation pools [6]. A typical example is shown in Fig. 2. A solution of a cation Al" ( cation pool ), which is generated by... 

Yoshida J, SugaS (2002) Basic concepts of cation pool and catirai flow methods and their applications in conventional and combinatorial organic synthesis. Chem Eur J 8 2650-2658... 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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