Combinatorial chemistry molecular tags

Nestler, H. P Bartlett, P. A., Still, W. C. A General Method for Molecular Tagging of Encoded Combinatorial Chemistry Libraries. J. Org. Chem. 1994, 59, 4723-4724. 

Nestler HP, Bartlett PA, Still WC, A general method for molecular tagging of encoded combinatorial chemistry libraries, J. Org. Chem., 59 4723 4724, 1994. 

Another recent reporP uses a set of chemically robust aryl fluorides as molecular tags. These molecules exhibit chemical shifts that range from -55 to -25 ppm relative to fluorobenzene, and are tolerant to a wide variety of chemical transformations in solid-phase chemistry. Poly-A-alkylglycines were chosen as a model system for the preparation of combinatorial... 

The availability of several dye tags with several distinguishable excitation and emission has already been exploited for purposes of identifying combinatorial chemistry libraries on beads, but the broad nature of molecular absorption and emission spectra puts a bandwidth limit on the number of dyes that can be practically applied. The logic approach mentioned in the previous paragraph can increase the diversity available with a single color combination manifold times. 

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