Column Dimensions and Film Thickness with Parameters in the Fundamental Resolution Equation

Correlation of Column Dimensions and Film Thickness with Parameters in the Fundamental Resolution Equation 

Column inner diameter affects not only resolution but also sample capacity. For example, the megabore column has an excellent capacity at the expense of a sacrifice in resolution offered by the narrower-diameter columns. Analysis times are also shorter, and of course, it remains the choice of choice for direct replacement of a packed column. But it is a column of choice for purity or trace component 

Thick films are necessary for separations of low boilers, thin-film columns for high boilers. As the column i.d. increases, thicker films are often selected thicker films of stationary phase also mean more column bleed (Section 3.8). One must 

Let us now review the fundamental resolution expression [equation (2.13)], which is repeated here for convenience, and examine each term on the right-hand side  

Efficiency, N, is a function of the carrier gas (i.e., helium vs. hydrogen vs. nitrogen, and column length and diameter. Doubling column length yields a 41% in resolution quadrupling of colunm length doubles resolution but at the expense of a fourfold increase in both time of analysis and cost. The question to be asked Is it worth it  

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