Colonic targeting HPMA

FIGURE 4.5 Schematic representations of HPMA copolymers designed for colon-specific drug targeting. Key to abbreviations is found in text. (From Minko, T., Adv. Drug Deliv. Rev., 56, 491, 2004. With permission.)... 

Wroblewski, S., et al. 2000. The influence of a colonic microbiota on HPMA copolymer lectin conjugates binding to rodent intestine. J Drug Target 8 173. 

David A, Kopeckova P, Minko T, Rubinstein A, Kopecek J. Design of a multivalent galactoside ligand for selective targeting of HPMA copolymer-doxorubicin conjugates to human colon cancer cells. Eur J Cancer 2004 40 148—157. 

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