Colonic targeting absorption

Colonic targeting has gained increasing interest over the past years. A considerable number of publications dealing with colon targeting, colon-specific drug delivery, and absorption from the cecum and other colon sections indicates a growing focus of research activities in this area. 

Katsuma, M., Watanabe, S., Kawai, H., Takemura, S., Sako, K. (2006). Effects of absorption promoters on insulin absorption through colon-targeted delivery. International Journal of... 

The pharmacokinetics of XYZ1234 formulations after release in different regions of the gastrointestinal tract reveal similar exposure for the proximal small bowel as compared to the immediate release formulation, halved exposure for the distal small bowel and only poor absorption from the ascending colon. Thus colonic resorption cannot be relied on for the development of an extended release formulation. Analysis of the scintigraphic data has confirmed release of the formulation at the target locations in the required number of subjects. 

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