Colon, drug absorption

Colonic Drug Absorption and Metabolism, edited by Peter R. Bieck... 

M Tomita, M Shiga, M Hayashi, S Awazu. Enhancement of colonic drug absorption by the paracellular permeation route. Pharm Res 5 341-346, 1988. 

An increasing number of preclinical and clinical studies have been conducted in recent years aiming to clarify the barrier function of the colonic epithelium in more detail and to devise drug delivery strategies, for example, by modulating factors limiting colonic drug absorption. For preclinical... 

Cheek, J.M., Kim, K.-J., and Crandall, E.D., NOj decreases paracellular resistance to ion and solute flow in alveolar epithelial monolayers, jcp. Lung Res., 16 561-575 (1990). Rangachari, P.K., Prior, T., and MeWade, D., Epithelial and mucosal preparations from canine eolon responses to substanee P, J. Pharmacol Exp. Ther., 254 1076-1083 (1990). Tomita, M., Hayashi, M., Toshiharu, H., and Awazu, S., Enhancement of colonic drug absorption by the transcellular permeation route, Pharm. Res., 5 786-789 (1988). 

Bieck, P.R. 1993. Colonic drug absorption and metabolism. New York Marcel Dekker. 

Swenson ES, Milisen WB, Curatolo W (1994) Intestinal permeability enhancement structure-activity and structure-toxicity relationships for nonylphenoxypolyoxyethylene surfactant permeability enhancers. Pharm Res 11 1501-1504 Tomita M, Hayashi M, Horie T, Ishizawa T, Awazu S (1988) Enhancement of colonic drug absorption by the transcellular permeation route. Pharm Res 5 786-789 Tomita M, Sawada T, Ogawa T, Ouchi H, Hayashi M, Awazu S (1992) Differences in the enhancing effects of sodium caprate on colonic and jejunal drug absorption. Pharm Res 9 648-653... 

Table 4 Some common colonic drug absorption enhancers...

Spiller, R.C. Stool water content and colonic drug absorption contrasting effects of lactulose and codiene. Pharm. 

Faigle, J.W. (1993) Drug metabolism in the colon wall and lumen, in Colonic Drug Absorption and Metabolism, Marcel Dekker Inc, Tubingen, pp. 29-54. 

Hebden, J.M., Gilchrist, P.J., Perkins, A.C., Wilson, C.G. and Spiller, R.C. (1999) Stool water content and colonic drug absorption contrasting effects of lactulose and codeine. Pharmaceutical Research, 16, 1254-1259. 

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