Colocation sites

The rapid development of colocation sites around the world is enabling ever more companies to execute this concept of disaggregation and focus (Fig. 4.3). To-... 

Annexin V-functionalized crosslinked iron oxide (CLIO) was designed as a contrast agent for MRI, which was additionally labeled with Cy5.5 to allow colocalization with optical imaging techniques [98]. Alternatively, conjugation of multiple Gd-DTPA molecules or SPIO particles to the C2 domain of synaptotagmin I was shown to allow the detection of apoptotic cells in vitro [99]. Zhao et al. [100] were the first to apply a C2 domain-functionalized SPIO and showed very promising results for future in vivo applications of MR contrast agents for the detection of apoptotic sites. 

Robinson, I. M., Finnegan, J. M., Monck, J. R., Wightman, R. M. and Fernandez, J. M. Colocalization of calcium entry and exocytotic release sites in adrenal chromaffin cells. Proc. Natl Acad. Sci. U.S.A. 92 2474-2478,1995. (Full Text in PMC)... 

Craig, S. W., and Pardo, J. V. (1983). Gamma actin, spectrin, and intermediate filament proteins colocalize with vinculin at costameres, myofibril-to-sarcolemma attachment sites. Cell Motil. 3, 449-462. 

The wide distribution of DA receptors in the brain brings about the obvious consequences of the presence of more than one subtype of these receptors in the same brain sites. This does not necessarily imply, however, a colocalization of different DA receptors in single cells. 

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