Collocated monolithic support structures

Slentz et al. [23] described nanocapillary electrochromatography on collocated monolithic support structures (COMOSS) molded in PDMS. The authors fabricated a chromatographic channel by molding COMOSS directly. In addition, the ability to separate biological samples such as peptides from a... 

To increase the surface area of the stationary phase for CEC separation, a collocated monolithic support structure (COMOSS) was constructed in a Si chip. A polystyrene-sulfonic acid stationary phase was then immobilized [349]. Design of the COMOSS required that the combined cross sectional area at the column head to be the same at any point in the inlet distributor [644]. A study for the reduction of band broadening in COMOSS was also reported [645]. 

Slentz, B.E., Penner, N.A., Lugowska, E., Regnier, F., Nanoliter capillary electrochromatography columns based on collocated monolithic support structures molded in polyfdimethyl siloxane). Electrophoresis 2001, 22, 3736-3743. 

He, B., Regnier, F., Microfabricated liquid chromatography columns based on collocated monolith support structures. J. Pharm. Biomed. Anal. 1998, 17, 925-932. 

Slentz, B. E., Penner, N. A., and Regnier, R, Geometric effects of collocated monolithic support structures on separation performance in microfabricated systems, J. Sep. ScL, 25, 1011, 2002. 

The column itself can be produced as a single open channel or as a branched system of channels starting from one microchannel and ending in another microchannel. The latter type is often named as COMOSS (collocated monolith support structure). With some of the materials mentioned, the channels can serve as stationary phase itself or can be functionalized by coating, packing, or incolumn polymerization with appropriate chromatographic phases. 

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