Nanocapillary Electrochromatography

Basically, capillary electrochromatography (CEC) is a hybrid technique of HPLC and CE [1-3], which was developed in 1974 by Pretorius et al. [4]. CEC is expected to combine high peak efficiency, which is a characteristic of electrically driven separations, with high separation selectivity. As is the case for electrophoresis, a voltage is applied across the separation plateform and sample moves via electroosmotic flow (EOF). However, in analogy to liquid chromatography, the separation device contains a solid 

Nanochromatography and Nanocapillary Electrophoresis. By Ali, Aboul-Enein, and Gupta Copyright 2009 John Wiley Sons, Inc. 

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Slentz et al. [23] described nanocapillary electrochromatography on collocated monolithic support structures (COMOSS) molded in PDMS. The authors fabricated a chromatographic channel by molding COMOSS directly. In addition, the ability to separate biological samples such as peptides from a... 

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