Collision-induced dissociation period

As with the quadmpole ion trap, ions with a particular m/z ratio can be selected and stored in tlie FT-ICR cell by the resonant ejection of all other ions. Once isolated, the ions can be stored for variable periods of time (even hours) and allowed to react with neutral reagents that are introduced into the trapping cell. In this maimer, the products of bi-molecular reactions can be monitored and, if done as a fiinction of trapping time, it is possible to derive rate constants for the reactions [47]. Collision-induced dissociation can also be perfomied in the FT-ICR cell by tlie isolation and subsequent excitation of the cyclotron frequency of the ions. The extra translational kinetic energy of the ion packet results in energetic collisions between the ions and background... 

The formation of methylsilver and dimethylargentate has been observed in the collision-induced dissociation MS3 spectrum of silver diacetate. Dimethylargentate is stable in the gas phase, and has been isolated for short periods (10 s) without significant decomposition.10... 

B. B. Reinhold, S.-Y. Chan, S. Chan, and V. N. Reinhold, Profiling glycosphingolipid structural detail Periodate oxidation, electrospray, collision-induced dissociation and tandem mass spectrometry, Org. Mass Spectrom., 29 (1994) 726-746. 

DCIM-MS has been coupled to liquid chromatography (LC) for analyzing complex peptide samples [36], Peptides eluting from the LC column were analyzed on an IMS-Q-TOF mass spectrometer. The ions generated from the source were accumulated in an ion trap and injected periodically into the drift tube. After mass analysis by the quadrupole, ions were subjected to collision-induced dissociation (CID) within an octopole collision cell and the product ions were analyzed by a TOF analyzer. Using this instrumental configuration, the urinary proteome [37], the Drosophila melano-gaster head proteome [38], and the human plasma proteome [39] have been analyzed. While many additional measurements, compared to standard mass spectrometry-based proteomics experiments, were obtained (for example, collision cross-sections), these were not used to improve upon protein identification results. 

Rodgers, M.T., Stanley, J.R. and Amunugama, R. (2000) Periodic trends in the binding of metal ions to pyridine studied by threshold collision-induced dissociation and density functional theory. J. Am. Chem. Soc., 122, 10969-10978. 

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