Collision-induced dissociation mass spectra

Wang PP, Bartlett MG (1998) Collision-induced dissociation mass spectra of cocaine, and its metabolites and pyrolysis products. J Mass Spectrom 33 961-967... 

Field desorption - collision induced dissociation mass spectra of seven disaccharides, involving alkali metal-cationized... 

FIGURE 9.14 Collision-induced dissociation mass spectra of Qo, using helium as the target gas at (a) low [20%], (b) medium [80%] and (c) high [98%] attenuation. (Reprinted with permission from reference 11). 

Hines, W.M., Falick, A.M., Burlingame, A.L. and Gibson, B.W., Pattern-based algorithm for peptide sequencing from tandem high energy collision-induced dissociation mass spectra. J. Am. Soc. Mass Spectrom., 3, 326-336 (1992). 

Figure 5 Collision induced dissociation mass spectra of (A) CHsOH and (B) CH20H2. Note the intense signal for the doubly charged ion in (B).

Nacson, S. Harrison, A. G. Davidson, W. R. Effect of Method of Ion Preparation on Low-Energy Collision-Induced Dissociation Mass Spectra. Org. Mass Spectrom. 1986, 21, 317 319. 

Collision-induced dissociation mass spectrum of tire proton-bound dimer of isopropanol [(CH2)2CHOH]2H. The mJz 121 ions were first isolated in the trap, followed by resonant excitation of their trajectories to produce CID. Fragment ions include water loss mJz 103), loss of isopropanol mJz 61) and loss of 42 anui mJz 79). (b) Ion-molecule reactions in an ion trap. In this example the mJz 103 ion was first isolated and then resonantly excited in the trap. Endothennic reaction with water inside the trap produces the proton-bound cluster at mJz 121, while CID produces the fragment with mJz 61. 

Figure 10 (A) Surface-induced dissociation spectrum of the pyrene molecular ion mlz202) with a stainless steel surface at a collision energy of 100 eV. (B) Collision-induced dissociation mass spectrum of the pyrene moelcular ion (miz 202) with Ar under single collision condiitons. Note that the mIz axis is not aligned or the same scale between (A) and (B). Adapted with permission fron Riederer Jr DE, PhD Thesis, Purdue University, 1993.

Figure 8 (A) Surface-induced dissociation mass spectrum produced from 30 eV collisions of W(CO)6 + miz 352) with an 8 pm thick liquid perfluoropolyether surface. (B) Calculated internal energy distribution for the spectrum in (A) using the thermometer molecule method. Figure 8A reproduced with permission from Pradeep T, Miller SA and Cooks RG (1993) Surface-induced dissociation from a liquid sur ce Journal of American Society for Mass Spectrometry A 769-773.

Time-of-flight mass spectrometers have been used as detectors in a wider variety of experiments tlian any other mass spectrometer. This is especially true of spectroscopic applications, many of which are discussed in this encyclopedia. Unlike the other instruments described in this chapter, the TOP mass spectrometer is usually used for one purpose, to acquire the mass spectrum of a compound. They caimot generally be used for the kinds of ion-molecule chemistry discussed in this chapter, or structural characterization experiments such as collision-induced dissociation. Plowever, they are easily used as detectors for spectroscopic applications such as multi-photoionization (for the spectroscopy of molecular excited states) [38], zero kinetic energy electron spectroscopy [39] (ZEKE, for the precise measurement of ionization energies) and comcidence measurements (such as photoelectron-photoion coincidence spectroscopy [40] for the measurement of ion fragmentation breakdown diagrams). 

Figure F4.5.1 Positive ion fast atom bombardment (FAB) with collision-induced dissociation (CID) tandem mass spectrum of pyropheophytin a isolated from spinach leaves. The FAB matrix was 3-nitrobenzyl alcohol.

Collision-induced dissociation FAB/MS/MS spectrum of an oligonucleotide containing a modified base. Reproduced (modified) from Iden C.R. and Rieger R.A., Biomed. Environ. Mass Spectrom., 18, 617, 1989, with permission. 

Desorption chemical ionization (DCI) mass spectrum of natural cocoa butter and collision-induced dissociation DCI/MS/MS traces of deprotonated molecular ions of 887 Th (A), 859 Th (B) and 831 Th (C). Reproduced (modified) from Stroobant V., Rozenberg R., Bouabsa E.M., Deffense E. and de Hoffmann E., J. Am. Soc. Mass Spectrom., 6, 498-506, 1995, with permission. 

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