Collision induced decomposition

Ions can be induced to fragment by increasing an electric potential known as a cone voltage, which speeds them. Accelerating the ions causes them to collide more energetically with neutral molecules, a process that causes them to fragment (collision-induced decomposition). 

R. S. Johnson, S. A. Martin, K. Biemann, J. T. Stults, and J. T. Watson, Novel Fragmentation Process of Peptides by Collision-Induced Decomposition in a Tandem Mass Spectrometer Differentiation of Leucine and Isoleucine. Anal. Chem., 59(1987) 2621-2625. 

Johnson R.S., Martin S.A., Biemann K., Stulz J.T., and Watson J.T. (1987), Novel fragmentation process of peptides by collision-induced decomposition in a tandem mass spectrometer differentiation of leucine and isoleucine, Anal. Chem. 59, 2621-2625. 

Bordas-Nagy, J. Jennings, K.R. Collision-Induced Decomposition of Ions. Int. J. Mass Spectrom. Ion Proc. 1990, 100, 1 OS-131. 

The mass spectrum of compound 1 and of its 3-deutero derivative has been reported.33 Apart from a strong molecular ion, the principal feature is a peak at 91 m.u. due to a C6H5N radical ion. This ion or interconverting ions 139-141, which are obtained from many other compounds, heterocyclic and nonheterocyclic, have been studied by the technique of collision-induced decomposition (CID).210 A study of some triazolopyridine-7-methanols has shown that other pathways, notably loss of the CHN2 fragment, can become important.23... 

Jennings, K.R. (2000) The changing impact of the collision-induced decomposition of ions in mass specrometry. hit. J. Mas Spectrom., 200,479. 

Yuan, M., Namikoshi, M., Otsuki, A., and Sivonen, K. 1998. Effect of amino acid side-chain on fragmentation of cyclic peptide ions differences of electrospray ionization collision-induced decomposition mass spectra of toxic heptapeptide microcystins containing ADM Adda instead of Adda. EurMass Spectrom 4 287-298. 

We may compare the shock reaction with the collision-induced decomposition (CID), because both reactions are characterized by the production of H2 and... 

Jennings, K. R. Collision-induced decompositions of aromatic molecular ions. Int.. Mass Spectrom. Ion Rhys. 1 227-235, 1968. 

As an example, it is difficult to distinguish the structures of the protonated molecules MH produced from isomeric compounds with the elemental formula CgHioO (cyclohexanone, cyclohexane oxide and 1,4-cyclohexane ether) [152] on the basis of their respective unimolecular decomposition spectra. Indeed, only the loss of water was observed in the MIKE spectra of these products. Collision-induced decomposition spectra (MIKE/CAD), on the other hand, lead to an easy structural distinction (Fig. 28). 

In order to obtain more intense molecular peaks, Levsen and co-workers [197] chose the field ionization (FI) method, much softer than electron impact ionization, and utilized collision-induced decompositions rather than unimolecular decompositions. They were thus able to identify estrone (m/z 270) and progesterone (m/z 314) in an artificial mixture (Table 13). The FI/MIKE/CAD spectra of the molecular ions are... 

Dunholke et al. [211] studied collision-induced decompositions of MH ions produced by Cl with B/ linked scan mode. It was shown that these ions, in spite of collisions in the first FFR, generated only a limited number of fragment ions, which nonetheless permitted their identification. In the same report, the authors similarly sought the presence of certain prostaglandins (prostaglandin-2) which under... 

The use of collision-induced decompositions was introduced by McLafferty and co-workers in 1974 [218] in a study of the peptide AcN-Gly-Ala-Leu-OCHj and its fragment ions produced by electron impact (Fig. 67). 

Collision-induced decompositions of the RCOO ion characterize the dipeptide A(d0)jO. leading to the identification of the C-terminal residue (Fig. 76). 

These complex mixtures may be studied by MS/MS, utilizing the spontaneous (or collision-induced) decompositions in the field free regions. This type of study may be pursued at both the structural and assay levels, without the need for transformation of considerable prior separations of the components of the mixture. 

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