Collagen/PCL

Powell HM, Boyce ST (2009) Engineered human skin fabricated using electrospun collagen-PCL blends morphogenesis and mechanical properties. Tissue Eng A 15(8) 2177-2187... 

Scaffolds made with collagen/PCL blend were compared with PCL scaffolds with [160] their surface modified by plasma treatment (p-PCL). p-PCL scaffolds were greater substrates for Schwann cells. The cells expressed bipolar elongations, retaining their normal morphology on the p-PCL fibers. p-PCL is a cost-effective material compared to PCL/collagen scaffolds, especially for peripheral nerve regeneration... 

Haslauer C M., Moghe A.K., Osborne J.A., Gupta B.S. and Loboa E.G., Collagen-PCL sheath-core bieomponent eleetrospun scaffolds increase... 

Case study collagen/PCL bicomponent nanofiber scaffolds for engineering bone tissues... 

The average fiber diameter in the PCL monocomponent scaffolds was 280 51 nm and the average thickness of the web was approximately 200 pm. The collagen-PCL sheath-core scaffolds also exhibited uniform fiber diameters with an average diameter of 442 45 nm and scaffold thickness of approximately 180 pm. ... 

Similarly, live/dead images from fluorescence microscopy revealed viable cells on both scaffolds (not shown). However, the calcium content from each of the three hASC lines after 14 days of culture in osteogenic medium showed significantly higher calcium deposition on the collagen-PCL bicomponent scaffolds as compared to that on the pure PCL controls. On average,... 

This study has shown that covering PCL with collagen greatly increased calcium deposition, signifying an increase in the number of osteodifferenti-ated hASCs. This illustrates the potential offered by collagen/PCL bicomponent nanoliber scaffolds for engineering bone tissues. 

Collagen/elastin, electrospun collagen/PCL, poly[(D,L-lactide)-co-glycolide]/coUagen Glutaraldehyde cross-linked gelatin... 

Dip coating while simple and cost effective does not always lead to a continuous uniform shell layer as obtained in coaxial electrospinning. A comparison of the relative effectiveness of collagen/PCL core-shell nanofiber mats and coUagen-coated PCL nanofiber mats as scaffolding for human dermal fibroblasts (HDF) was carried out by Y. Z. Zhang et al. (2005c). 

A similar composite based on the PCL/coUagen was also studied as substrate for skin tissue engineering. The results revealed that composite films of collagen/PCL composites are favorable substrates for the growth of fibroblasts and keratinocytes and provide adequate system for skin repair [40]. Multilayered polyelectrolyte films synthesized from hyaluronic acid, coUagen, and poly(ethyleneimine), were investigated for their in vitro response as chondrosarcoma cells proliferation with interestingly tunable antitumor properties [41] (Table 14.3). 

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