Collagen molecular organization

Linsenmayer, T. F., Gibney, E., Igoe, F., Gordon, M. K., Fitch, J. M., Fessler, L. I., and Birk, D. E. (1993). Type-V collagen Molecular-structure and fibrillar organization of the chicken alpha-1 (V) NH2-terminal domain, a putative regulator of corneal fibrillogenesis./. Cell Biol. 121, 1181-1189. 

Schematic representation of the molecular organization of structural elements in cartilage matrix. Collagen fibrils provide tensile forces, and proteoglycans, because of their large solvent domains, accommodate reversible compressible forces. LP = link protein HA = hyaluronate KS = keratan sulfate CS = chondroitin sulfate PC = core protein. [Reproduced with permission from L. C. Junqueira, J. Carneiro, and J. A. Long, Basic Histology, 5th ed. Appleton Lange, Norwalk, CT, 1986. 1986 Appleton-Century-Crofts.]...

Katz, E.P. and Li, S.T. 1972. The molecular organization of collagen in mineralized and nonmineralized tissues. Biochem. Biophys. Res. Commun. 3 1368-1373. 

The Structure of the a-Keratins Was Determined with the Help of Molecular Models The fi-Keratins Form Sheetlike Structures with Extended Polypeptide Chains Collagen Forms a Unique Triple-Stranded Structure Globular Protein Structures Are Extremely Varied and Require a More Sophisticated Form of Analysis Folding of Globular Proteins Reveals a Hierarchy of Structural Organization... 

The mineralized matrix of bone tissue is strained when loaded. Macro-molecular mechanical connections between the extracellular matrix and the osteocytic cell membrane exist and these connections may be capable of transmitting information from the strained extracellular matrix to the bone cell nuclear membrane. The basis of this mechanism is the physical continuity of the transmembrane integrin molecule, which is connected extracellularly with the macromolecular collagen of the organic matrix and intracellularly with the... 

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