Colic, renal indinavir

Drug-specific toxicities ritonavir, gastrointestinal distress saquinavir, hard gel capsules indinavir, renal colic nelfinavir, diarrhea amprenavir, nausea and vomiting. Increased risk of poor adherence with long-term treatment, leading to resistance... [Pg.240]

Kohan AD, Armenakas NA, Fracchia JA. Indinavir urohthiasis an emerging cause of renal colic in patients with human immunodeficiency virus. J Urol 1999 161(6) 1765-8. [Pg.1738]

Example A study in 1,219 patients of the ATHENA (AIDS Therapy Evaluation National Centre) cohort of patients infected with HIV receiving antiretroviral therapy in the Netherlands showed a frequency of urological symptoms (including nephrolithiasis, renal colic, flank pain, hematuria, renal insufficiency, or nephropathy) of 8.3 per 100 treatment-years for indinavir compared to 0.8 per 100 treatment-years for other HIV protease inhibi-... [Pg.87]

Padberg J, Eritsche L, Bergmann E, Schurmann D, Suttorp N. Nephropathy and renal colic in patients treated with indinavir, ritonavir plus indinavir or ritonavir plus saquinavir. AIDS 1999 13 2173-2174. [Pg.397]

Patients with indinavir crystalluria may be asymptomatic or develop clinical features of renal colic, flank or back pain, dysuria, urinary urgency, fever, nausea and vomiting. Pyuria and microscopic or, less corn-... [Pg.255]

A unique and common adverse effect of indinavir is crystalluria and nephrolithiasis. This stems from the poor solubility of the drug, which is lower at pH 7.4 than at pH 3.5. Precipitation of indinavir and its metabolites in urine can cause renal colic, and nephrolithiasis occurs in... [Pg.348]

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