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Simvastatin Colchicine

This topic has been re-analysed in a systematic review of published papers, in which relevant information from a total of 34 patients was identified (163). AU but two patients were also taking concomitant drugs known to affect the muscles, among which glucocorticoids, simvastatin, lovastatin, colchicine, and pyrazinamide were the most frequently cited. Ciclosporin is therefore difficult to implicate in most patients, but at least one case with positive ciclosporin re-administration supported a causative role. The clinical picture was non-specific, with myalgia, cramps, and muscle weakness, sometimes associated with raised serum creatine kinase activity, and heterogeneous histopathology. FinaUy, skeletal muscle abnormalities have rarely been described in patients without muscle symptoms. [Pg.753]

Clinically important, potentially hazardous interactions with alprazolam, aprepitant, astemizole, atorvastatin, benzodiazepines, carbamazepine, chlordiazepoxide, cilostazol, clonazepam, clorazepate, colchicine, conivaptan, cyclosporine, dabigatran, dasatinib, diazepam, digoxin, dihydroergotamine, disopyramide, ergot alkaloids, fesoterodine, fluoxetine, flurazepam, fluvastatin, HMG-CoA reductase inhibitors, imatinib, ixabepilone, lapatinib, lopinavir, lorazepam, lovastatin, methylprednisolone, methysergide, midazolam, nilotinib, oxazepam, paroxetine, pimozide, pravastatin, prednisone, quazepam, repaglinide, rimonabant, rivaroxaban, sertraline, silodosin, simvastatin, solifenacin, temazepam, temsirolimus, tolvaptan, trabectedin, triazolam, warfarin, zidovudine... [Pg.132]

Three case reports describe myopathy or rhabdomyolysis in patients given colchicine with fluvastatin, pravastatin or simvastatin. It seems possible that this interaction could occur with colchicine and any statin. [Pg.1099]

Hsu W-C, Chen W-H, Chai M-T, Chiu H-C. Colchicine-induced acute myqxithy in a patient with concomitant use of simvastatin. Clin Neuropharmacol (2002) 25,266-8. [Pg.1099]


See other pages where Simvastatin Colchicine is mentioned: [Pg.114]    [Pg.151]    [Pg.114]    [Pg.151]    [Pg.635]    [Pg.420]    [Pg.114]    [Pg.151]    [Pg.1099]   
See also in sourсe #XX -- [ Pg.1099 ]




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Colchicin

Simvastatin

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