Protein design coiled coils

Kohn, W. D., and Hodges, R. S. (1998). De novo design of alpha-helical coiled coils and bundles Models for the development of protein-design principles. Trends Biotech-nol. 16, 379-389. 

The above results show how combining the principles of supramolecular coordination chemistry with those of de novo protein design can produce a new family of metal-peptide nanoassemblies in which metal coordination is used to promote the formation of a-helical coiled-coils having discrete molecular... 

At the top of the SCOP hierarchy are 11 different classes alpha, beta, alpha and beta (a/p), alpha plus beta (a + p), multidomain proteins, membrane and cell-surface proteins, small proteins, coiled coil proteins, low-resolution protein structures, peptides, and designed proteins. Note that only the first seven classes are true classes. The remaining ones serve as place holders for protein domains that cannot (yet) be classified among the major classes and are maintained in SCOP for the sake of completeness and compatibility with the PDB. 

The design and study of the replicating system was based on the simple a-helical coiled-coil protein folding motif, for which the factors contributing to the thermodynamic and kinetic stability of the helical ensembles are well... 

Cohen, C., Parry, D.A.D. a-Helical coiled coils and bundles how to design an a-helical protein. 

---