Cognition enhancer, huperzine

Zangara A. (2003) The psychopharmacology of huperzine A An alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer s disease. Pharmacol BiochemBehav 75 675-686. 

Hyperzia serrata (Thunb.) Trev. Shi Shan (root) Huperzine A, isovanihyperzine A.33 Active cognition enhancer, treat senile dementia including Alzeheimer s disease. 

Huperzine A (49) is a sesquiterpene alkaloid isolated from a traditional Chinese herbal remedy, Huperzia serrata ( Qian Ceng Ta ) in 1986 [128], This compound has been proved to be a potent, selective and reversible acetylcholinesterase (AChE) inhibitor, and demonstrated memory enhancement and neuroprotective functions in clinical trials as a therapeutic against Alzheimer s disease (AD) in the People s Republic of China [129, 130], In 2004, a phase II clinical trial focused on its cognitive function was initiated by the National Institute on Aging (NIA) in the United States [131], ZT-1 (50), considered more selective than huperzine A, was developed as a semi-synthetic derivative of 49 by cooperation of the Shanghai Institute of Materia Medica and Debiopharm of Switzerland and is currently... 

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