Biosynthesis coenzyme A

Spry, C., Kirk, K, and Saliba, K.J. (2008) Coenzyme A biosynthesis An antimicrobial drug target. FEMS Microbiol. Rev. 32, 56-106. 

Brohn, F. H., and Trager, W. (1975). Coenzyme A requirement of malaria parasites Enzymes of coenzyme A biosynthesis in normal duck erythrocytes and erythrocytes infected with Plasmodium lophurae. Proc. Natl. Acad. Sci. USA 72, 2456-2458. 

Pantothenate kinase phosphorylates Vitamin B6, the first and rate controlling step in Coenzyme A biosynthesis. Due to the lack of pantothenate kinase inhibitors and activators, the exact physiological role of this enzyme in metabolism and disease is not yet known. In a recent study aimed at the discovery of antimicrobial agents, a set of novel inhibitors of S. aureus pantothenate kinase were disclosed that also inhibited mammalian (murine) pantothenate kinase with high micromolar IC50 values.235 A team at St. Jude Children s Hospital studied a library of known bioactive compounds to find inhibitors of pantothenate kinase. Several inhibitors with IC50 values below 10 pM were identified.236... 

Coenzyme A biosynthesis NOD of pantetheine-phosphate [E] and [A] 36 Cloned from Homo sapiens, assay, pathway 36... 

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