Coding Region feature

The International Sequence Database Collaborators also started assigning accession, version numbers to protein sequences within the records. Previously, it was difficult to reliably cite the translated product of a given coding region feature, except... 

A feature must always have a location. This is the Seq-loc that states where on the sequence the feature resides. A coding region s location usually starts at the ATG and ends at the terminator codon. The location can have more than one interval if it is on a genomic sequence and mRNA splicing occurs. In cases of alternative splicing, separate coding region features are created, with one multi-interval Seq-loc for each isolated molecular species. 

The genetic code is assumed to be imiversal unless explicitly given in the Coding Region feature. When the genetic code is not followed at specific positions in the sequence—for example, when alternative initiation codons are used in the first position, when suppressor tRNAs bypass a terminator, or when selenocysteine is added —the Coding Region feature allows these anomalies to be indicated. 

Because the majority of submissions contain a single nucleotide sequence and one or more coding region features (and their associated protein sequences), the functionality just outlined can frequently result in a finished record, ready to submit... 

Figure 39-19. Structure of a typical eukaryotic mRNA showing elements that are involved in regulating mRNA stability. The typical eukaryotic mRNA has a 5 noncoding sequence (5 NCS), a coding region, and a 3 NCS. All are capped at the 5 end, and most have a polyadenylate sequence at the 3 end. The 5 cap and 3 poly(A) tail protect the mRNA against exonuclease attack. Stem-loop structures in the 5 and 3 NCS, features in the coding sequence, and the AU-rich region in the 3 NCS are thought to play roles in mRNA stability.

Other applications of neural networks in bioinformatics include the recognition of protein sequence features such as transmembrane domains (Jacoboni et al., 2001) and recognition of features in DNA sequences (promoters (Matis et al., 1996 Nair et al., 1995), coding regions (Cai Chen,... 

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