Cobalt mutagenic effects

Although the addition of cobalt salts to cultures of human leukocytes and of diploid fibroblasts caused a reduction in the mitotic index, no evidence of mutagenicity was obtained. Similar conclusions were drawn in studies of the effects of cobalt with bacterial test systems (Carson et al. 1986). 

Elinder C-G (1984) Carcinogenic, mutagenic and teratogenic effects of cobalt. Plenary Lecture. In Workshop on Carcinogenic and/or Mutagenic Metal Compounds, Geneva. J Toxicol Environ Chem 7 251-256. 

Papageorgiou 1, Yin ZR, Ladon D, Baird D, Lewis AC, Sood A, et al. Genotoxic effects of particles of surgical cobalt chrome alloy on human cells of different age in vitro. Mutat Res Fundam Mol Mech Mutagen 2007 619 45-58. 

Table 9. Effect of cobaltous chloride and manganous chloride on mutagenic activity of quercetin.

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