CMF regimen

MTHFR Gene Polymorphism in Breast Cancer Patients Receiving CMF Regimen... 

CMF regimen is a combination of cyclophosphamide, MTX, and 5-FU, and represents one of the treatments of choice for women with non-metastatic breast cancer, significantly increasing disease-free and overall survival. A recent report in a... 

The major indications for melphalan are in the palliative therapy of multiple myeloma and cancers of the breast or ovary. Because it does not produce alopecia, melphalan is occasionally substituted for cyclophosphamide in the CMF regimen for breast cancer. 

Fluorouracil has been the mainstay of treatment of gastrointestinal tract tumours for the last 50 years. Combined with cyclophosphamide and methotrexate, the so-called CMF regimen is a gold standard treatment for many women with either early or advanced breast cancer. 

Breast carcinoma Postoperative chemotherapy commonly involves use of the CMF regimen (cyclophosphamide, methotrexate, and fluorouracil) with or without tamoxifen, or the CAP regimen in which doxorubicin (Adriamycin) replaces methotrexate. Tamoxifen (or toremifene) is added to such regimens for receptor-positive cancers, and trastuzumab may be included if tumors overexpress HER2 protein. 

Two patients taking iow-dose methotrexate had a toxic skin reaction when they started to use a cream containing fluorouracil. The activity of systemic treatment with methotrexate and fluorouracii are said to be dependent on the order in which the two drugs are given, but this does not appear to be important in the commoniy used CMF regimen. 

FU) -the CMF portion of this regimen is given every 21 days for 8 ... 

CMF cyclophosphamide, methotrexate, fluorouracil (regimen) DCIS ductal carcinoma in situ DPS disease-free survival ER estrogen receptor... 

Interestingly, those who started on doxorubicin-containing regimens experienced fatigue immediately, while patients who received a combination therapy with CMF (cyclophosphamide, methotrexate, and fluorouracil) did not report fatigue until after the fifth cycle of chemotherapy. ... 

Other cases of overanticoagulation have been reported with warfarin and fluorouracil-based regimens including CMF (cyclophosphamide, methotrexate and fluorouracil), - CMF plus vincristine and prednisone, fluorouracil, cisplatin and etoposide, and fluorouracil, cispla-tin and mitomycin."... 

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