Clusiaceae

There is, therefore, a need for original coxibs, and one might think to look into the medicinal flora of Asia and the Pacific, as an increasing body of evidence suggests the families Apocynaceae, Clusiaceae, Asteraceae, Polygonaceae, Lamiaceae, and Con-volvulaceae to elaborate ast sources of biomolecules which are able to inhibit the enzymatic activity of COX. 

A total of 515 xanthones have been identified in 20 families of higher plants, mainly in the Bonnetiaceae and Clusiaceae families (Vieira and Kijjoa 2005). Mangosteen fruit, a typical southeast Asian fruit, is the characteristic dietary source of xanthones (less than 7-8 mg/100 g FW) (Walker 2007). Mangostin is a C-glucosylxanthone that is also found in by-products of mango at high concentration levels (Barreto and others 2008). 

Dirhamno side C27H32O15 596 Hypericum japonicum Clusiacea Aerial 274... 

Hypericum perforatum (Clusiaceae), commonly known as SJW, is used in many countries for the treatment of mild-to-moderate forms of depression. Several clinical studies provide evidence that SJW is as effective as conventional synthetic antidepressants (46-51). From a phytochemical point of view, H. perforatum belongs to one of the best-investigated medicinal plants. A series of bioactive compounds have been detected in the crude material, namely phenylpropanes, flavonol derivatives, biflavones, proanthocyani-dins, xanthones, phloroglucinols, some amino acids, naphthodianthrones, and essential oil constituents (Fig. 3) (52-54). 

Geranyl-2,4,6-trihydrOxy-benzophenone (phenolic ketone) Tovomita krukovii (Clusiaceae) Candida albicans secreted aspartic protease (109 pM) [36]... 

Betulinic acid (lupane triterpene) Widespread Tovomita krukovii (Clusiaceae), Diospyros perigrina (Ebenaceae) Aminopeptidase N (7 pM) [68]... 

Kolaviron (mixture of (J-3/ C-8-linked biflavonoids) [LARI 1 (6,3, 4 -Tri-hydroxy-5,7,8-trimethoxy-flavone)] (flavone) Garcinia cok (Clusiaceae) AR (rat lens)... 

There are two apparently unrelated centres of xanthone production in the Angiospermae the Clusiaceae and the Gentianaceae. With respect to the former, the occurrence of xanthones in such genera as Bonnetia and Archytaea has been cited as powerful evidence for allying them to the Clusiaceae rather than the Theaceae (Kubitzki et al, 1978). 

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