Clozapine gastrointestinal

Antipsychotics should be tapered slowly before discontinuation. Abrupt discontinuation of antipsychotics, especially low-potency EGAs and clozapine, can result in withdrawal symptoms, felt to be a manifestation of rebound cholinergic outflow. Insomnia, nightmares, headaches, gastrointestinal symptoms (e.g., abdominal cramps, stomach pain, nausea, vomiting, and diarrhea), restlessness, increased... 

Gastrointestinal A fatal case of paralytic ileus 9 days after initiation of clozapine is reported in a 65-year-old male [131 ]. He was also on a reducing dose of olanzapine and did have a remote history of small bowel obstruction. Another case of paralytic ileus is reported in a 40-year-old male treated with clozapine and quetiapine [132 ]. A case of... 

Gastrointestinal Ischaemic colitis has been associated with phenothiazine antipsychotics, clozapine and olanzapine likely due to anticholinergic activity [179 ]. 

Gastrointestinal A case of pseudo-inflammatory bowel disease in a 34-year-old male on quetiapine, with previous recent history of ischaemic colitis with clozapine is reported [222 ]. 

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